Although naturally occurring proteins form stable defined tertiary structures, it is well known that many proteins with non-natural sequences have unstructured conformations 1,2. This suggests that ...

Imagining that protein stability needs to be kept within some limits for biological function is easy. However, is there any corresponding pressure on protein folding and, hence, the dynamic ...

Circular arrangement is one of the interesting topics of Permutations. Before understanding circular arrangement let us review some important concepts of linear ...

To run CIRPIN, load CIRPIN/trained_models/CIRPIN_model/CIRPIN_model_5k_cp_epoch301.pt To run Progres, load CIRPIN/trained_models/Progres_model/Progres_trained_model.pt ...

Using a technique called circular permutation, researchers at the University of California Berkeley have created a new suite of Cas9 variants called Cas9-CPs, which will simplify design of Cas9-fusion ...

We studied the effect of deleted and circularly permuted mutations in sperm whale myoglobin and present here results on three classes of mutants: (i) a deletion mutant, Mb 1-99, in which the ...

Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, United States Center for Synthetic Biology, Northwestern University, Evanston, Illinois 60208, ...

Virus-like particles (VLPs) are self-assembling nanoparticles derived from viruses with potential as scaffolds for myriad applications. They are also excellent testbeds for engineering protein ...

Find complete chapter notes of Permutation and Combination including topics like permutation, linear permutation, circular permutation, combination, relationship between permutation and combination ...