Imaging entire cells in the human brain is a task close to impossible, due to the tremendously sophisticated morphology of neurons and their spread throughout the entire organ. Organoids (as below) allow the recapitulation of the human brain to a certain extent, including the production of neurons from neuronal stem cell cultures. With ECi clearing, neuronal morphology can be studied from the local to global level, which opens up fascinating possibilities for the study of neuronal morphology in