#497 Tailoring and Ramping up Management of Methamphetamine Use Disorder for the Current Era

Methamphetamines (meth) is a highly addictive stimulant that affects your sense of reward, motivation, the experience of pleasure, and motor function. Chronic use affects dopaminergic neurons in limbic reward system structures such as the VTA and nucleus accumbens. These effects underlie addiction. Meth affects dopamine. It disrupts the dopamine neurotransmitter system, causes excess release of dopamine to leak out of vesicles, and overwhelms the process of reuptake and the process of enzyme bre