The schematic illustrates the comprehensive pipeline for Mendelian randomization analysis, starting with multi-omics data inputs from GWAS, eQTL, and pQTL studies, sourced from major databases such as ...

The instrument variable assumptions imply that all trains leaving the departure station (genetic variant) and arriving at the destination (outcome) must pass through the exposure station. They can ...

Mendelian randomization, a powerful tool in medical research, helps us understand whether certain factors truly cause disease. This technique uses genetic variations as "natural experiments" to reveal ...

Serum C-reactive protein (CRP), an important inflammatory marker, has been associated with age-related macular degeneration (AMD) in observational studies; however, the findings are inconsistent. It ...

A new study identifying 56 non-clinical risk factors associated with sudden cardiac arrest (SCA), spanning lifestyle, physical measures, psychosocial factors, socioeconomic status, and the local ...