Observational studies generally provide less reliable evidence than well designed randomised trials and systematic reviews and meta-analyses of such trials. Their results can be affected by ...

Systematic reviews of health care interventions most often focus on randomized controlled trials. However, certain circumstances warrant consideration of observational evidence, and such studies are ...

Mutational Analysis of Patients With Colorectal Cancer in CALGB/SWOG 80405 Identifies New Roles of Microsatellite Instability and Tumor Mutational Burden for Patient Outcome Comparative efficacy ...

Introduction Observational studies in health-related research often aim to answer causal questions. Missing data are common in these studies and often occur in multiple variables, such as the exposure ...

In their recent article in Journal of Clinical Oncology, Soni et al 1 compared findings from randomized controlled trials (RCTs) in oncology with analogous observational comparative effectiveness ...

Humans learn from observing others. Here, we show that such observational learning processes influence the extent to which a person empathizes with the pain of another individual. In our study, female ...

Background: Existing study quality and risk of bias lists for observational studies have important disadvantages. For this reason, a comprehensive widely applicable quality assessment tool for ...