Background: Immunohistochemical studies use antibodies to stain tissues with the goal of quantifying protein expression. However, protein expression is often heterogeneous resulting in variable ...

Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma has unique biology and better outcomes. p16 immunostaining is used as a surrogate marker for transcriptionally active HPV.

1 Anatomy Section, Universidad de Los Andes School of Medicine, Bogotá, Colombia 2 Healthy Brain Aging and Sleep Center, New York University (NYU) Langone Health, New York, NY, United States ...

Objective: To establish a rapid and effective method for en-bloc hematoxylin-eosin (HE) staining and paraffin embedding of human lung cancer and paracancerous tissues which can be applied to ...

A RIKEN research team has established an optimized three-dimensional (3D) tissue-staining and observation technique based on existing tissue clearing technology. Published in Nature Communications, ...

Diagnostically reliable identification of prostatic basal cells has depended on staining for high molecular weight cytokeratin. The diagnosis of malignancy is often based on the absence of basal cells ...

Researchers at Graz University of Technology found that ordinary espresso can replace toxic uranyl acetate for electron ...

A RIKEN research team has established an optimized three-dimensional (3D) tissue-staining and observation technique based on existing tissue clearing technology. Published in Nature Communications, ...

In many cases, researchers are faced with the need to detect two or more antigens in a single tissue specimen. The creates an issue called ‘colocalization’, where an antibody binds to multiple ...

Negative staining is a powerful preparative method for studying particulate specimens. In principle, the specimen is surrounded by heavy metal atoms that act as an electron barrier. Because the ...