Adopting a Quality by Design (QbD) approach for wet granulation requires manufacturers to comprehend the correlation between process variables, such as powder characteristics and equipment ...

Granulation is a critical unit operation in pharmaceutical manufacturing, where fine powders are agglomerated into granules to improve flow properties, uniformity, and compaction performance. The ...

A pharmaceutical tablet is defined as a solid dosage form containing drug material normally with suitable diluents and prepared either by compression or molding methods. Drug formulation and design ...

The unit selected for wet granulation, whether it be a high shear mixer or a fluidised bed, has a marked impact on granule properties. The unit selected for wet granulation, whether it be a high shear ...

In dry granulation, powders bind because of the application of mechanical stress. As particles are forced to be within closer proximity, entrained air is forced out, bulk density increases, and a ...

The authors evaluate the scalability of foam-granulation technology using continuous foam addition in high-shear granulation equipment at the laboratory, pilot and manufacturing scales. Immediate- and ...