病気の変異を持ったままでも光明が見えてきた —— tRNA 修飾酵素でミトコンドリア病の治療を目指す —— [発表のポイント] 細胞中のごく微量なミトコンドリア tRNA中の化学修飾塩基を高感度に検出・定量する方法を開発しまた。 ミトコンドリア ...

タンパク質合成に重要な役割を担うtRNAに糖（ガラクトースおよびマンノース）を付加する酵素を2種類同定しました。 tRNAの糖付加修飾は適切な翻訳速度の調節を担うこと、またその分子基盤を明らかにしました。 これらのtRNA修飾の欠損はタンパク質 ...

理化学研究所（理研）脳神経科学研究センタータンパク質構造疾患研究チームのチェンウェン・チェン研究員と田中元雅チームリーダーの研究チームは、タンパク質合成中の転移RNA（tRNA）[1] の種類や量を詳しく解析する「tRNAリボソームプロファイリング法 ...

tRNAs have a distinct cloverleaf secondary structure and an L-shaped tertiary structure. The cloverleaf structure is formed by the folding of the single-stranded tRNA molecule, which is typically ...

New results from ultrafast spectroscopy and in-depth theoretical calculations demonstrate that the complex folded structure of tRNA is stabilized by magnesium ions in direct contact with phosphate ...

Archaeosine is synthesized via three steps in tRNA. ArcS, the second-step enzyme, transfers a lysine to preQ 0, which is introduced into tRNA by ArcTGT, the first-step enzyme. The resultant preQ 0-Lys ...

A groundbreaking study has shed light on the critical role of a tRNA methylation enzyme, TRMT10A, in supporting brain function. The findings reveal how the absence of TRMT10A leads to a reduction in ...

Imagine your body as a highly organised factory where workers tirelessly assemble proteins around the clock. These proteins are the machines and scaffolds that make up your body and are essential for ...

Researchers uncovered a previously unknown CRISPR immune response in bacteria that targets transfer RNAs. The newly ...

Researchers say discoveries could expand the CRISPR toolbox and lead to more efficient, rapid diagnostic tools for detecting COVID-19, influenza, and RSV.