Biomedical Sciences Department, School of Medicine, Creighton University, Omaha, NE, United States The spindle assembly checkpoint (SAC) is a surveillance mechanism that prevents uneven segregation of ...

Bipolar spindle assembly requires a balance of forces where kinesin-5 produces outward pushing forces to antagonize the inward pulling forces from kinesin-14 or dynein. Accordingly, Kinesin-5 ...

Figure 1: Ran-GTP stimulates the interaction between TPX2 and Eg2. Figure 2: TPX2 and microtubules stimulate phosphorylation of Eg2. Figure 3: TPX2-induced Eg2 phosphorylation is regulated by the Ran ...

Chromosome segregation errors in mammalian oocyte meiosis lead to developmentally compromised aneuploid embryos and become more common with advancing maternal age. Known contributors include ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Overexpression of the mitotic checkpoint ...

Cell division is essential to the propagation of life. During cell division, mitotic spindles segregate duplicated chromosomes with high fidelity. Spindle structure depends on the proper polar ...

This work explores how centrosomes, which function as the primary microtubule organizing center in animal cells, regulate cell division by examining the process in cells in which centrosome formation ...