Second-generation sequencing technologies have replaced array-based technologies and become the default method for genomics and epigenomics analysis. Second-generation sequencing technologies sequence ...

Smoothing splines have been used in generalised additive models (gams) to analyse environmental risk factors, such as air pollution, climate, and mortality, 15–17 and in epidemiological risk ...

Abstract: Some of the relationships between optimal control and statistics are examined. We produce generalized, smoothing splines by solving an optimal control problem for linear control systems, ...

Abstract: We introduce an extended class of cardinal L/sup */L-splines, where L is a pseudo-differential operator satisfying some admissibility conditions. We show that the L/sup */L-spline signal ...

Individual participant data (IPD) meta-analysis (MA) offer great opportunities, such as to simultaneously investigate effect modification while also modelling for potential non-linear association ...

Eisen and colleagues have provided a good example of the use of smoothing splines in a thorough analysis of exposure-response data, for a study of lung cancer in relation to silica exposure. 1 ...

This is a preview. Log in through your library . Abstract Modelling response surfaces using tensor cubic smoothing splines is presented for three designed experiments. The aim is to show how the ...