Europe PMC

Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment.

Human cardiac regeneration is limited by low cardiomyocyte replicative rates and progressive polyploidization by unclear mechanisms. To study this process, we engineer a human cardiomyocyte model to ...
ahajournals.org

Cronos Titin Is Expressed in Human Cardiomyocytes and Necessary for Normal Sarcomere Function

The giant sarcomere protein titin is important in both heart health and disease. Mutations in the gene encoding for titin (TTN) are the leading known cause of familial dilated cardiomyopathy. The ...
Europe PMC

Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy.

Hypertrophic cardiomyopathy (HCM) is caused by pathogenic variants in sarcomere protein genes that evoke hypercontractility, poor relaxation, and increased energy consumption by the heart and ...
eLife

Independent regulation of Z-lines and M-lines during sarcomere assembly in cardiac myocytes revealed by the automatic image analysis software sarcApp

This manuscript describes a useful tool for quantitative assessment of sarcomere structures in healthy and perturbed cardiomyocytes grown in vitro. The work is solid, and the methods, data and ...
Frontiers

Implications of S-glutathionylation of sarcomere proteins in cardiac disorders, therapies, and diagnosis

1 Department of Pharmacy Practice, College of Pharmacy, Chicago, IL, United States 2 Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, Chicago, IL, ...
PNAS

Myosin-binding protein H-like regulates myosin-binding protein distribution and function in atrial cardiomyocytes

Compared to the cardiac ventricle, there are significant knowledge gaps in the sarcomeric mechanisms responsible for normal atrial relaxation. The atrial myosin-binding protein, myosin-binding protein ...
eLife

Stochastic tug-of-war among sarcomeres mediates cardiomyocyte response to environmental stiffness

This study provides a valuable characterization of individual sarcomere's contractility and synchrony in spontaneously beating cardiomyocytes as a function of substrate stiffness. The authors, however ...
ahajournals.org

Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is caused by pathogenic variants in sarcomere protein genes that evoke hypercontractility, poor relaxation, and increased energy consumption by the heart and ...
openheart.bmj

Sarcomere mutation negative hypertrophic cardiomyopathy is associated with ageing and obesity

Background Despite advances in our understanding of the genetic causes of hypertrophic cardiomyopathy (HCM), a large portion of this patient population do not carry sarcomere gene mutations when ...