Pilot trials have a key role in preparing for definitive randomized trials, yet determining their sample size remains a common challenge. This article provides practical guidance, methods, and ...

Copyright: © 2025 The Author(s). Published by Elsevier Ltd. Rigorous study design and analytical standards are required to generate reliable findings in healthcare ...

Implementation of the Time-to-Event Continuous Reassessment Method Design in a Phase I Platform Trial Testing Novel Radiotherapy-Drug Combinations—CONCORDE BayeSize applies the concept of effect size ...