Choosing the proper sample size for an investigation is one of the crucial jobs required of a statistician. Regardless of whether the statistician is deciding the number of patients to select in a ...

Decentralized clinical trials (DCTs) are increasingly recognized and utilized in epidemiology studies and drug development. A critical step in designing DCTs is determining the sample size-a topic ...

Pilot trials have a key role in preparing for definitive randomized trials, yet determining their sample size remains a common challenge. This article provides practical guidance, methods, and ...

Case-control studies are among the most commonly used means of assessing association between exposure and outcome. Sample size determination and the optimal control-to-case ratio are vital to the ...

1 Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC 27599, USA 2 Department of Psychiatry, Washington University School of Medicine, St ...

Implementation of the Time-to-Event Continuous Reassessment Method Design in a Phase I Platform Trial Testing Novel Radiotherapy-Drug Combinations—CONCORDE BayeSize applies the concept of effect size ...

Copyright: © 2025 The Author(s). Published by Elsevier Ltd. Rigorous study design and analytical standards are required to generate reliable findings in healthcare ...