Cell reprogramming consists in the reverse process to cell differentiation, making cells lose their identity and age-related characteristics and granting an increased potential for proliferation and ...

Cellular reprogramming to a stem-cell-like state is inefficient and poorly understood, despite its biomedical potential. Detailed molecular analyses of this process are now reported, and should help ...

Outside the neurogenic niches, the adult brain lacks multipotent progenitor cells. In this study, we performed a series of in vivo screens and reveal that a single factor can induce resident brain ...

The lack of genome-wide mathematical models for the gene regulatory network complicates the application of control theory to manipulate cell behavior in humans. We address this challenge by developing ...

Cellular senescence and cellular reprogramming represent two fundamentally intertwined processes that profoundly influence aging and cancer. This paper explores how the permanent cell-cycle arrest of ...

Direct reprogramming of skin fibroblasts into tissue-specific cells (e.g. neurons, vascular cells, blood cells) is a relatively new research field which can potentially affect both tissue engineering ...

The adult heart is one of the least regenerative tissues in the human body. After hypoxemia from myocardial infarction (MI), cardiomyocytes undergo massive cell death, and resident cardiac fibroblasts ...

Defining mechanisms of cardiomyocyte proliferation should guide the understanding of endogenous cardiac regeneration and could lead to novel treatments for diseases such as myocardial infarction. In ...

The capacity of an organism to regenerate depends on cell dedifferentiation followed by proliferation. Mammals, in general, have limited regenerative capacity. Now, a team of researchers at the Salk ...

Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences; Beijing 100190, China Beijing ...

Stimulating a key metabolic pathway in T cells can make them work more effectively against tumors when combined with immune checkpoint inhibitor therapy, according to a preclinical study. The findings ...