CDT1 inhibits the helicase activity of the MCM complex, thereby suppressing nascent strand synthesis in DNA replication in cultured human cells. This action results in fork collapse and DNA damage, ...

Mouse ES cells present active origin firing and replication forks that progress slowly throughout S phase. These features are integral aspects of genome replication ensuring genome integrity in ES ...

Embryonic stem (ES) cells are pluripotent stem cells that can produce all cell types of an organism. ES cells proliferate rapidly and have been thought to experience high levels of intrinsic ...

To gain a deeper understanding of BKPyV replication and ways to prevent it, UAB researchers in the Department of Microbiology have published a single-cell analysis of BKPyV infection in primary kidney ...

From the blueprint of life encoded in our DNA to the awe-inspiring complexity of our genetic inheritance, we will embark on a journey through the microscopic world within us and witness the remarkable ...

Reactive oxygen species (ROS) were long regarded as harmful by-products of mitochondrial metabolism, but growing evidence—including our own—shows that ROS also signal to core processes such as ...