methods for causal inference using genetic variants chapter 1. 例. CRPが高い方が、(因果的に)心血管疾患になりやすいか？ 観察研究で、CRPが高い方が心血管疾患になりやすいことがわかっていた。しかし、年齢・性別その他交絡因子を調整すると関連は小さくなり、さらに ...

Although numerous Mendelian randomization studies on risk factors have been conducted in male medicine, a systematic synthesis of these findings is still lacking. This review searched relevant ...

Insomnia, a prevalent sleep disorder, poses significant threats to both physical and mental health. Traditional studies suggest multiple factors are associated with insomnia, yet the causal direction ...

Outcome-adaptive randomization is one of the possible elements of an adaptive trial design in which the ratio of patients randomly assigned to the experimental treatment arm versus the control ...

Abstract: Due to the inevitable information loss during IR lowering, compile-time metadata collection can provide more precise auxiliary information than binary analysis to achieve reliable ...