Journal of the Royal Statistical Society. Series B (Statistical Methodology), Vol. 79, No. 5 (NOVEMBER 2017), pp. 1439-1462 (24 pages) We propose a Bayesian decision theoretic model of a fully ...
The customary approach to early-phase clinical trial design, where the focus is on identification of the maximum tolerated dose, is not always suitable for noncytotoxic or other targeted therapies.
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