To investigate the influences of breviscapine, a flavonoid extracted from Erigeron breviscapus, on the proliferation and migration of vascular smooth muscle cells (VSMCs) cultured in a high glucose ...

In order to survive, cancer cells often rely on the protein kinase C epsilon (PKC-epsilon) signaling pathway to sort out tangled DNA that would otherwise trigger their destruction, according to a team ...

Diabetes. 2005;54(6):1615-1625. The polyol pathway, shown schematically in Fig. 2, focuses on the enzyme aldose reductase. Aldose reductase normally has the function of reducing toxic aldehydes in the ...

Over 13,000 articles published since 1966 seemed to show that all of these pieces of the puzzle were important in the pathogenesis of diabetic complications, yet two things suggested that something ...

An errant enzyme linked to bipolar disorder, in the brain’s prefrontal cortex, impairs cognition under stress, an animal study shows. The disturbed thinking, impaired judgment, impulsivity, and ...

Acetylcholine (ACh) is a neuromodulator with a central role in aversive learning - rapid conditioning to unpleasant smell, taste, or touch. These learning functions play out in cells called D2 ...