To investigate the ability of ox-LDL to induce ossification of endothelial progenitor cells (EPCs) in vitro and explored whether oxidative stress, especially hypoxia inducible factor-1α (HIF-1α) and ...

The development of the lower limb includes transformation of the cartilaginous skeleton into osseous one at the three consecutive stages, i.e. the ossification process first involves the shafts of ...

Ossification of ligamentum flavum (OLF) is a prevalent degenerative spinal disease, typically causing severe neurological dysfunction. Kruppel-like factor 5 (KLF5) plays an essential role in the ...

1 School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, China 2 Queen Mary School, Nanchang University, Nanchang, China Fibroblasts are integral to the pathological ...

We thank Dr. Fanxin Long for generously providing an important Col2a1-Cre ERT mouse strain and R. Yamaguchi, H. Kawahara, and D. Mori for technical assistance. This study was supported by ...

A Kyoto University research team has used iPS cells generated from the cells of patients with FOP (fibrodysplasia ossificans progressiva) to successfully replicate the pathological conditions of the ...

Version of Record: This is the final version of the article. In the present study, the authors examined the possibility of using phosphatidyl-inositol kinase 3-kinase alpha (PI3Ka) inhibitors for ...

This study, which includes additional experiments in response to the reviewer comments, presents valuable findings illustrating the role of PI3Kα in heterotopic ossification in FOP model mice. The ...