Researchers have revealed that so-called ‘junk DNA’ contains powerful switches that help control brain cells linked to Alzheimer’s disease. When people picture DNA, they often imagine a set of genes ...

多くの配列バリアントがヒトの複雑な形質や疾患と関連付けられてきたが、それらの大半はノンコーディングDNA上にあるために、その生物学的機能の解明はいまだに困難である。今回我々は、SNP-SELEX（single-nucleotide polymorphism evaluation by systematic evolution of ligands ...

Researchers have developed a method to swiftly screen the non-coding DNA of the human genome for links to diseases that are driven by changes in gene regulation. The technique could revolutionize ...

Deep-learning model decodes the regulatory effects of DNA changes ...

While it was once believed that genes regulated biological functions almost exclusively by being transcribed to coding RNAs that were then translated into proteins, it is now known that the picture is ...