The human genome contains about 20,000 protein-coding genes, but that only accounts for roughly two percent of the genome. For many years, it was easier for scientists to simply ignore all of that ...

多くの配列バリアントがヒトの複雑な形質や疾患と関連付けられてきたが、それらの大半はノンコーディングDNA上にあるために、その生物学的機能の解明はいまだに困難である。今回我々は、SNP-SELEX（single-nucleotide polymorphism evaluation by systematic evolution of ligands ...

細胞の性分化を阻止する長鎖ノンコーディングRNAを発見 細胞内で機能を持つノンコーディングRNAを探し出す方法の開発と実践 ＜発表のポイント＞ 細胞研究は従来、DNAや酵素などのタンパク質に着目されてきたが、近年、「ジャンク」とされていた一部の ...

Deep-learning model decodes the regulatory effects of DNA changes ...

For decades, scientists have been puzzled by large portions of the human genome labeled as “junk” DNA, sequences that seemingly serve no purpose. Yet, recent studies suggest these cryptic sequences ...

Researchers have revealed that so-called ‘junk DNA’ contains powerful switches that help control brain cells linked to Alzheimer’s disease. When people picture DNA, they often imagine a set of genes ...

Only around two percent of the human genome codes for proteins, and while those proteins carry out many important functions of the cell, the rest of the genome cannot be ignored. However, for decades ...

細胞内で機能を持つノンコーディングRNAを探し出す方法の開発と実践 細胞の性分化を阻止する長鎖ノンコーディングRNAを発見 細胞内で機能を持つノンコーディングRNAを探し出す方法の開発と実践 詳細は 早稲田大学Webサイトをご覧ください。 【表：https ...

While it was once believed that genes regulated biological functions almost exclusively by being transcribed to coding RNAs that were then translated into proteins, it is now known that the picture is ...