Neurulation is a well-known morphogenetic event of embryonic development that has important clinical consequences. The failure of neural tube closure leads to a group of common and severe ...

The image shows cross sections from four different developmental stages in the early embryo from gastrulation (flat) to the end of neurulation. Unexpectedly, the study revealed that stem cells that ...

Department of Developmental Neurobiology, Centre for Developmental Neurobiology and MRC Centre for Developmental Disorders, Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King's College ...

This is a fundamental study into human spinal neurulation, which substantially advances our understanding of human neural tube closure. Crucial unanswered questions in the field currently rely on ...

Failure of neural tube closure in the early embryo causes neural tube defects including spina bifida. Spina bifida lesions predominate in the distal spine, particularly after exposure to the ...

In the interests of transparency, eLife includes the editorial decision letter and accompanying author responses. A lightly edited version of the letter sent to the authors after peer review is shown, ...