Neural tube defects (NTDs) are severe congenital malformations affecting 1 in every 1000 pregnancies. 'Open' NTDs result from failure of primary neurulation as seen in anencephaly, myelomeningocele ...

In vertebrate embryos, the process of neurulation, which transforms a flat neural plate into a three-dimensionally patterned tube, relies on a sequence of morphogenetic events that are tightly ...