Neural tube defects (NTDs) are severe congenital malformations affecting 1 in every 1000 pregnancies. 'Open' NTDs result from failure of primary neurulation as seen in anencephaly, myelomeningocele ...

Apoptotic cell death occurs in many tissues during embryonic development and appears to be essential for processes including digit formation and cardiac outflow tract remodeling. Studies in the chick ...

In vertebrate embryos, the process of neurulation, which transforms a flat neural plate into a three-dimensionally patterned tube, relies on a sequence of morphogenetic events that are tightly ...