Join us for an in-depth webinar on Mendelian Randomization (MR), where we will guide you through the complete workflow of MR analysis—practical implementation. What You’ll Learn: The principles and ...

In this session, we will learn how to perform two Sample MR with publicly available GWAS datasets. The overall process in this session is mainly based on the TwoSampleMR in R vignette. This document ...

Mendelian randomization is a study design that uses genetic variants as instrumental variables to test the causal effect of a (non-genetic) risk factor on a disease or health-related outcome. Since ...

A major goal of epidemiology is to reduce the burden of disease in populations through interventions that target causal determinants of disease risk. Although observational studies, such as ...

This in-person three-day course will provide a comprehensive background to researchers interested in using Mendelian randomization for psychiatric research. The course will be a mixture of lectures ...

MR’s ability to mitigate confounding and reverse causality has positioned it at the forefront of causal inference. By integrating genetic, metabolomic, and clinical data, the studies in this Research ...

Although numerous Mendelian randomization studies on risk factors have been conducted in male medicine, a systematic synthesis of these findings is still lacking. This review searched relevant ...

ATP citrate lyase is an enzyme in the cholesterol–biosynthesis pathway upstream of 3-hydroxy-3-methylglutaryl–coenzyme A reductase (HMGCR), the target of statins. Whether the genetic inhibition of ATP ...