Effective protein characterization depends on the precise isolation and fragmentation of peptide ions within the mass spectrometer, typically coupled with liquid chromatography (LC-MS/MS). In a ...

Tandem mass spectrometry is a powerful tool in proteomics. By ionizing peptides and then fragmenting those ions into smaller product ions, researchers can determine the biomolecules’ amino acid ...

Ions are accumulated in the Zeno trap before being pulsed rapidly into the TOF, meaning up to 20x more fragment ions can be detected. Enabled by a new level of sensitivity, each MS/MS experiment ...

Chemical cross-linking mass spectrometry (CXMS) is an important tool for resolving protein structures and studying protein interactions. The technique uses a chemical cross-linking agent to link two ...

An algorithm designed by researchers from Carnegie Mellon University's Computational Biology Department and St. Petersburg State University in Russia could help scientists identify unknown molecules.

For decades, mass spectrometry has been the gold standard in proteomics because of its combination of specificity, sensitivity, high target plex, and lack of requirement for affinity reagents. Yet, ...

De novo sequencing is a method to analyze and identify peptide sequences and some post-translational modified proteins. Different from some other analysis methods, which depend on a known protein ...