A newly published study in Genes & Diseases highlights the crucial role of the mammalian target of rapamycin (mTOR) pathway in the progression of diabetic nephropathy (DN) and explores its potential ...

Yale researchers discovered that an underactive mTOR pathway drives structural malformations in lissencephaly. Using patient-derived brain organoids, they showed that activating the mTOR pathway ...

Network map of 29 authors with frequency greater than five. Nodes represent authors, and the larger the node, the higher the number of papers. The lines represent collaborations with other authors, ...

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動物を用いた2つの研究で、食餌からの分岐鎖アミノ酸の摂取を制限すると、mTORシグナル伝達経路が調節されて寿命が延びる可能性があることが示された。しかし、この食餌療法を人に推奨するには、さらなる研究が必要である。 食餌制限は寿命を延ばす ...

Gedatolisib's NDA for advanced breast cancer treatment has been accepted by the FDA, with a priority review and a PDUFA date ...

Lissencephaly is a spectrum of rare, genetic disorders in which the brain fails to develop its hallmark folds. The disorders are often associated with seizures and intellectual disability and ...