Gastrulation, a prerequisite for organogenesis, begins with the formation of the primitive streak (PS), where epiblast cells experience an epithelial-to-mesenchymal transition (EMT) to exit the ...

Uniting three different parameters in single cells taken from mouse embryos reveals more about how foundational cell identities are established in early development The first single-cell multi-omics ...

In their publication in Science, Professor Guojun Sheng (Kumamoto University, Japan), Professor Alfonso Martinez Arias (Universidad Pompeu Fabra, Spain) and Professor Ann Sutherland (University of ...

When the zygote, or the fertilised egg, starts to develop, the soon forming inner cell mass, a cluster of cells that will eventually develop into the individual, retains its pluripotent stem cell ...

How does the “body” take shape? The body of animals is highly complex, containing distinct regions that carry out specific functions. As the body forms during embryogenesis, three germ layers are ...

With the construction of a building, one of the first steps before creating the upright structure is to set the foundations and the floorplan. Mammalian development is not so different. A ...

A serendipitous discovery in the lab has the potential to revolutionize embryo models and targeted drug therapies. Materials scientists at UNSW Sydney have shown that human pluripotent stem cells in a ...

As a human embryo grows, a set of molecules directs cells as they multiply and take on specific identities and spatial positions within the embryo. In one crucial step known as gastrulation, these ...

Only two weeks after fertilization, the first sign of the formation of the 3 axes of the human body (head/tail, ventral/dorsal, and right/left) begins to appear. At this stage, known as gastrulation, ...