Over the past 20 years, naturally occurring mutations that affect G protein-coupled receptors (GPCRs) have been identified, mainly in patients with endocrine diseases. The study of loss-of-function or ...

Genes that encode G-protein-coupled receptors (GPCRs) and G proteins can have loss-of-function or gain-of-function mutations, which result in endocrine disorders Loss-of-function mutations in GPCRs ...

G protein-coupled receptors (GPCRs) are the largest class of cell surface receptors in our cells, involved in signal transmission across the cell membrane. One of the biggest questions is how a signal ...

This makes GPCRs of utmost importance as targets for modern drug development, while a large proportion of current clinical drugs target various GPCRs. Therefore, understanding how GPCRs function at a ...

Just Because a G-Protein Coupled Receptor Has Resisted Characterization Doesn’t Mean It Can’t Be Sighted—or Hunted For drug developers, G-protein coupled receptors (GPCRs) are dearly sought trophies.

This study is reported by Changtao Jiang’s group and Dongyu Zhao’s group from School of Basic Medical Sciences, Peking University. Adipogenesis is the healthy expansion of white adipose tissue (WAT), ...

A GPS-like technique has been used to track G protein-coupled receptor movement, revealing how these essential receptors function. Although G protein-coupled receptors (GPCRs) are crucial to the ...

PENZBERG, Germany--(BUSINESS WIRE)-- G-coupled protein receptors (GPCRs), also known as 7-transmembrane proteins, constitute the single largest class of therapeutic targets for clinical and ...

G protein-coupled receptors (GPCRs) are transmembrane proteins that transduce an extracellular signal—ligand binding—into an intracellular signal—activation of G-protein—which in turn activates ...