Isothermal titration calorimetry (ITC) is an analytical technique, which is often thought of as the gold standard for analyzing intermolecular interactions. It is a titrimetric method, which is a ...

An important goal in drug development is to engineer inhibitors and ligands that have high binding affinities for their target molecules. In optimizing these interactions, the precise determination of ...

All biochemical reactions involve recognition, binding, and the formation of noncovalent complexes. Many small molecule drugs act by selectively binding to protein or nucleic acid targets and altering ...