Viruses exploit the functions of the endoplasmic reticulum (ER) to promote both early and later stages of their life cycle, including entry, translation, replication, assembly, morphogenesis and ...

Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) have emerged as central regulators of immune cell function and inflammatory processes. The UPR, mediated by three principal ER ...

The endoplasmic reticulum (ER) is a very versatile organelle. Besides its major role as the gateway to the secretory pathway the ER is central to adaptation against abiotic and biotic stress. Here, we ...

The endoplasmic reticulum (ER) is a multifunctional organelle that is specialized for lipid synthesis, Ca2+ homeostasis, and protein synthesis. Protein synthesis is a multistep process involving ...

To elucidate the functional roles of mitochondrial dynamics in vivo, we identified genes that become essential in cells lacking the dynamin-related proteins Fzo1 and Dnm1, which are required for ...

Calcium (Ca2+) drives many cellular functions, though the way it controls quality of proteins in the endoplasmic reticulum ...

Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS Veselina Petrova, 1 Craig S. Pearson, 2 Jared Ching, 1,3,4 James R. Tribble, 5 Andrea G. Solano, 2 ...

Calreticulin is a protein with many roles, including calcium regulation and helping other proteins fold. How did scientists discover calreticulin and its functions? In their most basic state, proteins ...

Calcium (Ca2+) drives many cellular functions, though the way it controls quality of proteins in the endoplasmic reticulum ...

Introduction: Previously(Lassaletta et al,PMC3943541)we showed that Rapamycin treatment of normal pigs subjected to an acute myocardial ischemia-reperfusion injury (IRI) was associated with increase ...