The antibiotic cefazolin is an essential drug according to the World Health Organization (WHO). It is usually produced via batch manufacturing, but this multistep process is time-consuming, wasteful ...

Continuous pharmaceutical manufacturing represents a significant shift from traditional batch processing, integrating continuous flow methods, advanced process analytical technology (PAT) and ...

Aim: To demonstrate the potential of in-line nanoparticle size measurements using the NanoFlowSizer (NFS) as a PAT method. To achieve real-time process control by establishing automated regulation of ...

Imagine a future where rare diseases and devastating cancers can be swiftly treated with therapies produced directly in the clinic and tailored to a patient’s unique genetic profile. Common conditions ...

Continuous manufacturing and a quality-by-design development approach are a natural fit. FDA, as well as other regulatory agencies around the world, have for many years been encouraging drug makers to ...

Businesses often struggle to produce fine materials and nanomaterials at commercial scales. The U.S. Department of Energy’s (DOE) Argonne National Laboratory, long a leader in chemical process ...

Despite the advantages intensified processes can offer developers, there are still some obstacles to overcome before broader application of new technologies will be implemented. For some time now, the ...

The size and size distribution of nanomedicines in various (bio)pharmaceutical products, including liposomes, lipid nanoparticles, recombinant proteins, and antibodies, plays a significant role in ...