Adeno-associated virus (AAV) mediates gene targeting in humans by providing exogenous DNA for allelic replacement through homologous recombination. In comparison to other methods of DNA delivery or ...

Researchers from Tokyo Medical and Dental University (TMDU) and Ionis Pharmaceuticals, USA, report a modification wherein replacing the RNA strand of a heteroduplex oligonucleotide with DNA may ...

In the hours after a heart attack, an intravenous dose of the bacterial protein streptokinase can break up blood clots and restore circulation. But it’s not ideal: Like other clot-busting drugs, ...