Complement is an ancient defense mechanism that evolved into a large protein-interaction network in mammals that initiates and serves innate immune functions and links innate immunity with adaptive ...

“The whole is greater than the sum of its parts.” — Aristotle Figure 1: Complement-mediated intracellular and autocrine regulation of the activation of CD4 + T cells. The studies noted above have ...

The elimination of cancer cells critically depends on the immune system. However, cancers have evolved a variety of defense mechanisms to evade immune monitoring, leading to tumor progression.

1 Department of Microbiology and Immunology, Des Moines University, Des Moines, IA, USA 2 Department of Biologicial Sciences, California State University Long Beach, Long Beach, CA, USA Complement is ...

Complement molecules are the immune proteins responsible for identifying bacteria, viruses, and other foreign invaders as they circulate through our bodies. Their function helps lymphocytes to locate ...

Hemolytic uremic syndrome (HUS) is an important cause of acute renal failure in children. Mutations in one or more genes encoding complement-regulatory proteins have been reported in approximately one ...