Cancer cells are more resistant to complement-mediated lysis and use this attribute to set up a locally immunosuppressive environment. However, new findings suggest that tumor-driven complement ...

Complement molecules are the immune proteins responsible for identifying bacteria, viruses, and other foreign invaders as they circulate through our bodies. Their function helps lymphocytes to locate ...

Hemolytic uremic syndrome caused by an invasive Streptococcus pneumoniae infection (SP-HUS) is a rare and severe disease that primarily affects children under two years of age. The pathophysiology of ...

Atypical hemolytic uremic syndrome (aHUS) is a rare and severe form of thrombotic microangiopathy caused by genetic or acquired abnormalities of the alternative pathway (AP) of complement activation, ...

Background Anti-C1q autoantibodies can disrupt normal complement function, contributing to the formation of pathogenic immune complexes and end-organ damage. Although their role in SLE is ...