For the complement system to cause AMD, there must be initiation (a ‘trigger’), amplification, and local retinal damage caused by the process. The alternative pathway of the complement system is ...

Introduction: Hematopoietic stem cell transplantation (HSCT) is associated with immune complications and endothelial dysfunction due to intricate donor-recipient interactions, conditioning regimens, ...

Cancer cells are more resistant to complement-mediated lysis and use this attribute to set up a locally immunosuppressive environment. However, new findings suggest that tumor-driven complement ...

The domain of cancer treatment has persistently been confronted with significant challenges, including those associated with recurrence and drug resistance. The complement system, which serves as the ...

The complement system is integral to innate immunity and host defense. However, inappropriate activation causes host tissue damage and disease. In health, this is prevented by a complex protein ...

PHOENIX, Arizona—Nipocalimab might lower the concentration of anti-acetylcholine receptor antibodies, or anti-AChR antibodies, in people with generalized myasthenia gravis, reducing neuromuscular ...

Hemolytic uremic syndrome (HUS) is an important cause of acute renal failure in children. Mutations in one or more genes encoding complement-regulatory proteins have been reported in approximately one ...

The authors report a case of deficiency of the eighth component of complement in a young adult with a history of three episodes of meningitis; one of them proved to be meningococcal. The literature ...