Here, we describe a patient with an early onset of endocapillary glomerulonephritis and CFH deficiency. Genetic analyses revealed uniparental isodisomy and a novel mutation as the unusual molecular ...
Cutaneous squamous cell carcinoma (cSCC) is a common form of skin cancer with an estimated 750,000 cases diagnosed annually in the United States. Most cases are successfully treated with a simple ...
One of the three pathways of the complement system, the alternative complement pathway, plays a vital role in amplifying complement activation and pathway signaling. Complement factor D, a serine ...
School of Chemistry, University of Edinburgh, Edinburgh EH9 3JJ, U.K. School of Chemistry, University of Edinburgh, Edinburgh EH9 3JJ, U.K. Schools of Biological Sciences and Chemistry, University of ...
School of Chemistry, University of Edinburgh, Edinburgh EH9 3JJ, U.K. School of Chemistry, University of Edinburgh, Edinburgh EH9 3JJ, U.K. Schools of Biological Sciences and Chemistry, University of ...
Complement is a key component of the innate immune system; however, its dysregulation due to genetic mutations or the presence of autoantibodies can cause a number of diseases including age-related ...
The complement system is an essential component of the innate immune system that participates in elimination of pathogens and altered host cells and comprises an essential link between the innate and ...
1 Department of Otolaryngology, Division of Nephrology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA 2 Interdepartmental PhD Program in Genetics, Division of Nephrology, Carver ...
The complement system is a key component of innate and adaptive immune responses. Complement regulation is critical for prevention and control of disease. We have determined the crystal structure of ...
Copyright: © 2001 Elsevier Ltd. Published by Elsevier Ltd. The clinical picture of HUS related to factor H abnormality has emerged in two ways. The first was through ...
Deficiency in C3, but not in factor B, leads to more extensive atherosclerotic lesions, increased hyperlipidemia, and reduced body fat in Apoe−/− LDLR−/− mice. Complement activation by the classical ...
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