Due to their repetitive and complex DNA sequences, centromeres have been viewed as the "black boxes" of the genome for decades. Often overlooked in sequencing projects but playing a critical role in ...

Certain types of biochemical processes can impair the immune system’s ability to recognize and kill cancer cells. Purdue University’s W. Andy Tao and his associates have developed a new way to study ...

Researchers recently enhanced the titer of a cell line still in development to produce adenovirus viral vectors by 7.5-fold, and without the risk of also producing replication-competent adenoviruses ...

Successfully producing large quantities of biotherapeutics, including monoclonal antibodies and recombinant protein products, depends on robust and reliable cell line development (CLD). Issues that ...

To achieve this progress, biologic production has had to reinvent itself. Although biologics were once sourced directly from donated blood plasma or cells, the backbone of this process is now a ...

Advances in cell line engineering and microfluidic technologies offer substantial opportunities to shorten timelines in cell line development (CLD). However, as with any innovation, optimizing these ...

Industrial cell line development needs mammalian cell lines derived from one progenitor cell. Therefore, regulatory agencies ask to evaluate the probability of clonality (PoC) to ensure safe ...

Essentially all cells in an organism’s body have the same genetic blueprint, or genome, but the set of genes that are actively expressed at any given time in a cell determines what type of cell it ...