Nature

MHC class II expression is differentially regulated in plasmacytoid and conventional dendritic cells

Major histocompatibility complex (MHC) class II–restricted antigen presentation is essential for the function of dendritic cells (DCs). We show here that plasmacytoid DCs (pDCs) differ from all other ...
Nature

Regulation of MHC class II gene expression by the class II transactivator

MHC class II molecules are of central importance to the adaptive immune system. MHC-class-II-mediated peptide presentation is essential for positive and negative selection of CD4 + T cells in the ...
Frontiers

Soft tissue evaluation of functional therapy in growing patients with class II malocclusion: mandibular advancement vs. twin block—a retrospective study

1 Department of Health Science, UniCamillus-Saint Camillus International Medical University, Rome, Italy 2 Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy ...
EurekAlert!

A missing link in the MHC class divergence puzzle: Class II came first

Which came first, MHC class I or MHC class II? For decades, it has been debated which of these two similar classes came first in evolution. Now, Keiichiro Hashimoto and his group at Fujita Health ...
Dentistry

Managing class II malocclusion with Invisalign

Aligner Dental Academy outlines how digital advancements in orthodontics are transforming the diagnosis and treatment of class II malocclusion with Invisalign. Class II malocclusion, a common ...