The ability to design and build nonnative DNA sequences conferring specific and useful engineered functions on cells defines the field of synthetic biology. Here, we describe a synthetic biology ...

Circular permutation (CP) in a protein can be considered as if its sequence were circularized followed by a creation of termini at a new location. Since the first observation of CP in 1979, a ...

† Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322. United States ¶ Department of Biochemistry, Emory University, 1510 Clifton Rd., Atlanta, Georgia 30322, United ...

Multiple types of natural collagens specifically assemble and co-exist in the extracellular matrix. Although noncollagenous trimerization domains facilitate the folding of triple-helical regions, it ...

Although naturally occurring proteins form stable defined tertiary structures, it is well known that many proteins with non-natural sequences have unstructured conformations 1,2. This suggests that ...

∥ Centre for High Throughput Biology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z1 ⊥ Department of Biochemistry and Molecular Biology, University of British Columbia, ...

Imagining that protein stability needs to be kept within some limits for biological function is easy. However, is there any corresponding pressure on protein folding and, hence, the dynamic ...

Circular permutations usually retain the native structure and function of a protein while inevitably perturbing its folding dynamics. By using simulations with a structure-based model and a rigorous ...

Abstract: We consider the problem of sorting a circular permutation by super short reversals (i.e., reversals of length at most 2), a problem that finds application in comparative genomics. Polynomial ...

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