Dr. Vadim Jucaud's lab at the Terasaki Institute has developed a human vascularized liver cancer-on-a-chip model to evaluate vessel remodeling and cell death in response to embolic agents. This novel ...

T cells dynamically adapt to signals in the TME, transitioning between effector, exhausted, and regulatory states. Cellular interactions, metabolic stress, and physical barriers (e.g., ECM) shape ...

Novel Model Integrating TME Composition with TLS Gene Signatures Predicts Meaningful Survival Differences in Checkpoint Inhibitor-Treated Patients Cellworks Group Inc., a leader in Personalized ...

Pancreatic cancer cells are known for being hard to treat, partly because they change the environment around them to block drugs and immune cells. Scientists discovered that these tumors use a ...

Cancer represents a key challenge in medical science, manifesting as a disease where the immune system fails to recognize and eliminate tumor cells. The phenomenon of immune evasion by cancer cells ...

Cancer neuroimmunology integrates the study of the nervous system's influence on tumor immunity, highlighting an intricate ...

The tumor microenvironment (TME) consists of mediators surrounding a tumor, including diverse cell types, blood vessels, and other cellular components. Certain elements of the TME can benefit patients ...

Chimeric antigen receptor T (CAR-T) cell therapy has revolutionized hematologic cancer treatment, but its efficacy in solid tumors remains limited by poor infiltration into the complex tumor ...