Dr. Vadim Jucaud's lab at the Terasaki Institute has developed a human vascularized liver cancer-on-a-chip model to evaluate vessel remodeling and cell death in response to embolic agents. This novel ...

Solid tumors have dysfunctional vasculature that affects the delivery of nutrients to the TME. This limited availability of nutrients, including glucose, oxygen and amino acids, drives nutrient stress ...

Tsukuba, Japan—Follicular lymphoma is a common and recurrent form of malignant lymphoma. Although the role of T cells (a type of lymphocyte) in its development has been suggested, the diversity and ...

T cells dynamically adapt to signals in the TME, transitioning between effector, exhausted, and regulatory states. Cellular interactions, metabolic stress, and physical barriers (e.g., ECM) shape ...

Cancer neuroimmunology integrates the study of the nervous system's influence on tumor immunity, highlighting an intricate interaction that affects cancer progression and therapeutic outcomes. Recent ...

Pancreatic cancer cells are known for being hard to treat, partly because they change the environment around them to block drugs and immune cells. Scientists discovered that these tumors use a ...

Combination therapies represent a promising frontier in cancer treatment, addressing the critical need to enhance efficacy while minimizing resistance. By combining different therapeutic agents and ...

The tumor microenvironment (TME) consists of mediators surrounding a tumor, including diverse cell types, blood vessels, and other cellular components. Certain elements of the TME can benefit patients ...