Background Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality with limited therapeutic options. Despite ...

Antigen-driven TCR signaling in the epidermis during CD8+ TRM differentiation results in a lower TGFβ requirement for persistence and increased proliferative capacity that together enhance epidermal ...

CD8 T細胞と呼ばれる免疫細胞は、通常、病原体を殺傷するが、今回、自己反応性CD4 T細胞を抑制する亜集団の存在が示された。この細胞集団は、マウスを自己免疫疾患から防御していた。 免疫系は、複雑な機構を進化させることで、宿主自身の組織を温存し ...

New findings could aid future development of more efficient therapeutic strategies in the context of regenerative medicine and aging.

Investigators led by Navdeep Chandel, PhD, the David W. Cugell, MD, Professor of Medicine in the Division of Pulmonary and Critical Care, have discovered how the metabolism of mitochondria supports ...

Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy by harnessing the body's immune system to target ...