Germinal centers are high-speed evolution machines. Tiny clusters in the lymph nodes, germinal centers refine antibodies through mutation and expansion until they produce high-affinity B cells adapted ...

Autoimmune diseases comprise more than 80 different diseases that have in common a burden on health systems and are of unknown etiology. In general, in most countries, autoimmune diseases affect an ...

A recent Nature Immunology study explores the cellular and molecular adaptations associated with human secondary lymphoid tissue in adults during viral infection. Lymphoid tissues play a vital role in ...

Finland was the first country to offer the zoonotic avian influenza A(H5N8) vaccine manufactured by Seqirus to at-risk occupational groups following the extensive clade 2.3.4.4b A(H5N1) outbreak ...

Researchers highlight how exercise and dietary strategies may complement immunotherapy by improving immune function, tumour perfusion, and quality of life.

Vaccination was linked to lower inflammation scores, slower epigenetic, transcriptomic aging, and a lower composite biological aging score.

CD8 + cytotoxic T lymphocytes (CTLs) serve as central effectors in cancer immunotherapy by directly eliminating tumor cells. However, current clinical therapies face significant limitations. These ...

Researchers have shown that innate immune training, also known as trained immunity (TRIM), leads to aggravated bone loss in experimental models of periodontitis and inflammatory arthritis. Clinical ...